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The SURPASS program established efficacy in type 2 diabetes across multiple comparators, including head-to-head superiority versus semaglutide on HbA1c reduction in SURPASS-2 (Fras et al., NEJM, 2021)

It was required to incorporate dose less than or equal to 20 mg per patch and still deliver at least sufficient amount at the end of 24 hrs considering half-life of around or less than 2 hrs

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Nu b rng tc qu nhiu khi ung creatine, bn hy th gim liu lng hoc i sang 1 sn phm creatine cht lng hn

Free Radic Biol Med 25:287297 Lopez-Lluch G, Hunt N, Jones B, Zhu M, Jamieson H, Hilmer S, Cascajo MV, Allard J, Ingram DK, Navas P, de Cabo R (2006) Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

That means less repair, less energy, and slower recovery